Players from all 20 Premier League clubs will be in action during the final international break of 2024.
In Europe, countries are participating in the latest round of UEFA Nations League fixtures.
A depleted England squad, missing names such as Cole Palmer, Declan Rice and Phil Foden through injury, face Greece in Athens on Thursday, before returning to Wembley Stadium on Sunday to host a Republic of Ireland squad that has eight Premier League players, including Liverpool goalkeeper Caoimhin Kelleher.
These will be England's final matches under interim head coach Lee Carsley before former Chelsea manager Thomas Tuchel takes over in January.
The other two standout ties from the week are Belgium (featuring Amadou Onana and Leandro Trossard) v Italy (Sandro Tonali and Destiny Udogie) on Thursday and Denmark v Spain the following day.
See: UEFA Nations League fixtures and permutations
In South America, qualifying for the 2026 FIFA World Cup continues as two Liverpool team-mates compete for a place in the United States and Mexico in two years.
Luis Diaz and Colombia will travel to face club colleague Darwin Nunez and Uruguay on Friday, as the nations placed second and third look to cement their positions inside the top six qualifying spots.
Group leaders and World Cup holders Argentina, with seven Premier League players in their squad, go to Paraguay, where Julio Enciso will face former Brighton & Hove Albion team-mate Alexis Mac Allister on Thursday.
A Brazil squad featuring Bruno Guimaraes, Gabriel, Gabriel Martinelli and Savinho will travel to Venezuela, aiming to extend the three-point gap on the teams below them in fourth position.
See: CONMEBOL World Cup qualifying fixtures
It is also World Cup qualifying time in Asia where South Korea and Japan teams containing Premier League stars such as Son Heung-min and Kaoru Mitoma are hoping to consolidate top spot in their groups, with ties against Kuwait and Palestine, and Indonesia and China, respectively.
See: AFC World Cup qualifying fixtures
In Oceania, Nottingham Forest striker Chris Wood has two matches in his native New Zealand, against Vanuatu on Friday and Samoa on Monday as the Kiwis aim to build on their winning start to World Cup qualification.
See: Oceania World Cup qualifying fixtures
In Africa, qualifying matches for the African Cup of Nations in Morocco 2025 will take place from Wednesday through to Saturday.
Five players from the Premier League, including Brighton's Simon Adingra and the Forest pair of Willy Boly and Ibrahim Sangare, are in the Ivory Coast squad travelling to Zambia.
Ghana has eight Premier League players, including Mohammed Kudus and Jeffrey Schlupp, on their trip to Angola.
